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CellFlo® Max Modules


Production Scale Hollow Fiber Modules for Processing 1,000 to 50,000 Liters!

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Spectrum introduced the KrosFlo® MAX & CellFlo MAX, our largest hollow fiber filter modules available for the bioprocessing & pharmaceutical industries. These production modules directly scale up from KrosFlo Plus & CellFlo Plus (excluding the R85 and R65 lengths) to provide surface areas ranging from 5.4 to 17.3 m2. KrosFlo MAX & CellFlo MAX modules can be operated with the KrosFlo Pilot Plus, Pharma or LDF 55 TFF Production System as well as production system designed by Spectrum to combine and MAX-imize the advantages of gentle hollow fiber flow dynamics, the efficiency of tangential flow filtration and the time & cost savings of disposability. MAX-imize your process filtration!

GENERAL DESCRIPTION


Disposable CellFlo MAX are available in three convenient sizes. The "300" size provides a direct scale-up of the process volume, flow rate & permeate rate from Spectrum's CellFlo Plus "3X" size. The "600" and "800" sizes are easy retrofits for commercially available re-usable modules. All three sizes can be connected to any process loop via 2" sanitary retentate ports and 1-1/2" sanitary filtrate ports. Non-irradiated modules can be sterilized once prior to use by autoclaving, irradiation or ETO.

QUALITY ASSURANCE


Spectrum modules are manufactured under cGMP in an ISO class 20 E (US Fed. Class 10,000) cleanroom and are 100% integrity tested and 100% lot traceable. All material of construction meet class VI biocompatibility standards.

Dimensions:
Modules SizeSA (m2)Scale LengthD (cm)TL (cm)L (cm)EL (cm)
xxxx-601-xxx4.4 - 4.7R6511.673.562.849.9
xxxx-301-xxx6.0 - 6.43xFL11.691.581.267.9
xxxx-801-xxx9.5 - 10.1R8511.6131.1120.6107.5

Specifications:

Housing:Clear and Pigmented Polysulfone
Netting:Polypropylene
Flange Nut:Pigmented polysulfone
Inlet/Outlet Reducer:2" sanitary, clear polysulfone
Filtration Side-port:1-1/2" sanitary
Potting:Polyurethane
Process Volume:50 - 5,000 liters
Surface Area:4.4 - 10.1 m2
MembraneFiber IDMWCO
Mixed Cellulose Ester (ME)1.0 mm0.2 µm
Polyethersulfone (PES)1.0 mm0.2 µm, 0.5 µm (not available in 801 series)
Polysulfone (PS)1.0 mm100 kD

Advantages of Disposability

  • Easier FDA Validation
  • Saves Money & Time
  • No Cross-Contamination
  • Less Down-Time
  • Low Shear
  • Directly Scalable for Production
  • Easy Retrofit for other HF Modules

CellFlo Max Applications

  • Whole cell washing & concentration
  • Cell harvesting
  • Continuous bioreactor perfusion
  • Large diagnostic particle diafiltration
  • Clarification of viral cultures
  • Nanofiltration
  • Colloid Concentration
  • Virus Purification & Concentration


Filtration Resources:

Product Literature
Fundamentals of Filtration
Spectrum's Competitive Edge
Our HF Membranes vs. Others
Scalability of Process Modules
Application Guide
Chemical Compatibility Chart
Pore Size Chart


RELATED PRODUCTS:

KrosFlo Max Module Wrench
Learn More >

KrosFlo Pilot Plus System
for volumes up to 2,000 L
Learn More >

KrosFlo LDF-55 System
for volumes from 50 to 750+ L
Learn More >

Custom Production System
Learn More >

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