 | |
The new KrosFlo SIP Modules combine the benefits of hollow fiber tangential flow filtration (TFF) with a robust
design for processes requiring SIP and product re-use. Validated for 5 SIP cycles, these superior filter modules
incorporate a thermally stable potting compound with a durable membrane support sleeve to withstand the
extreme conditions of multiple steam sterilization cycles and NaOH cleaning/sanitization. Ideal
for production scale applications, the KrosFlo SIP Modules can be operated singly to process
50 to 1,000 liters or in parallel up to 10,000 liters. Efficient and Re-usable!
The Size C version of the KrosFlo SIP Modules is specifically
designed for production scale applications with 4.4 m2
(1.0 mm ID fibers) and 6.0 m2 (0.5 mm fibers). Scaling up
from the "2X" or "3X" length MiniKros® KrosFlo® and
CellFlo® disposable modules, the Size C SIP modules easily
and securely fits into Spectrum's Size C, stainless steel
KrosFlo SIP Housing, as well as retrofitting other commercially
available SIP housings. The SIP module and housing assembly can be connected to any SIP process system
via 2" sanitary retentate ports and 1-1/2" sanitary filtration ports.
Spectrum modules are manufactured under cGMP in an ISO class 209 E (US Fed. Class 10,000) cleanroom and are
100% integrity tested and 100% lot traceable.
Dimensions:  |
| Assembly Component | D (cm) | TL (cm) | L (cm) | EL (cm) |
| Size C SIP Module | 10.8 | 62.2 | 62.2 | 53.3 |
| Size C SIP Housing | 11.4 | 77.1 | N/A | N/A |
|
| Sleeve: | Clear & Pigmented Polysulfone |
| Potting: | Epoxy |
| Membrane: | PES or PS |
| Seals, Size C: | White silicone |
|
| Cylinder, Side-port, 1-1/2" Sanitary: | Stainless Steel |
| End-cap, Reducer, 4" - 2" Sanitary: | Stainless Steel |
| Clamps, 4" Sanitary: | Stainless Steel |
| Gaskets, 4" Sanitary: | Silicone |
| Membrane | Fiber ID | MWCO |
| Polyethersulfone | 1.0 & 0.5 mm | 0.2 µm & 0.5 µm |
| Polysulfone | 0.5 mm | 0.05 µm, 20 nm (500 kD), 100 kD, 50 kD & 10 kD |
The KrosFlo SIP Modules are validated for 5 SIP cycles.
- Pre-soak the module in water for 2 hrs.
- Pre-warm installed SIP assembly at 100°C for 30 min.
- Steam at 121°C for 30 min.
- Cool the module for at least 4 hrs.
WARNING: Change the temp. 1-2°C/min to avoid thermal shock.
- Flush the installed SIP assembly with buffer/water for 20 min.
- Flush the installed SIP assembly with 0.5N NaOH for 1 hr.
- Flush out NaOH with water or buffer.
WARNING: Flushing with water first may precipitate protein.
|
| |
