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MidiKros® Modules


Hollow Fiber Modules For Small Volume Process Separation

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Designed for tangential membrane process separations for small volumes, MidiKros disposable filters are practical devices suitable for processing volumes ranging from 20 mL to 200 mL.

These modules are an ideal alternative to centrifugation for applications where pellet formation is undesirable. Flow is supplied using a peristaltic pump. MidiKros modules are hollow fiber membranes encased in a polysulfone housing. MidiKros modules are scalable and autoclavable with a membrane surface area ranging from 20 to 145 cm2. They are also available irradiated (irr).

Process fluid is pumped through the inlet port, flows tangentially across the membrane lumenal surface and exits the opposite end of the module through the outlet port. While the majority of the stream and constituents is rejected and continues down stream, a small percentage passes through the membrane into the extra-capillary space as permeate.

Dimensions:
SA (cm2)Scale LengthID (mm)TL (cm)L (cm)EL (cm)
22-551/3xFL7.813.29.88.0
40-852/3xFL7.817.813.711.8
60-1451xFL7.825.822.220.3

Specifications:

Housing:Polysulfone
Connections:1/4 Hose Barb (HB) inlet and outlet
Female Luer Lok filtrate (FLL)
Potting:Polyurethane
Process Volume:20 mL to 200 mL
Surface Area:20 to 145 cm2

MembraneFiber IDMWCO
Mixed Cellulose Ester (ME)0.6 mm, 1.0 mm0.2 µm, 0.1 µm
Polyethersulfone (PES)0.5 mm, 1.0 mm0.5 µm, 0.2 µm
Polysulfone (PS)0.5 mm0.05 µm, 20 nm (500 kD), 100 kD, 50 kD, 10 kD

1.0 mm100 kD

Advantages of Disposability

  • Easier FDA Validation
  • Saves Money & Time
  • No Cross-Contamination
  • Less Down-Time
  • Low Shear
  • Directly Scalable for Production
  • Easy Retrofit for other HF Modules


Applications

  • Cell Washing
  • Lysate Clarification
  • Bacterial Concentration
  • Micro-particle Diafiltration
  • Macromolecular Isolation
  • Virus Purifications
  • Viral Clarification
  • Protein Purification
  • Antibody Production
  • Desalting & Buffer Exchange
  • NanoParticle Diafiltration

Filtration Resources:

Product Literature
Fundamentals of Filtration
Spectrum's Competitive Edge
Our HF Membranes vs. Others
Scalability of Process Modules
Application Guide
Chemical Compatibility Chart
Pore Size Chart


RELATED PRODUCTS:

KrosFlo Research II System
for volumes of 10 ml to 200 ml
Learn More >

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