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MiniKros® Modules


Disposable Hollow Fiber Tangential Flow Modules for Process Scale Volumes

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The MiniKros modules are perfectly suited for process optimization and scaling filtration applications up to the production volumes. Spectrum combines the gentle and highly efficient tangential flow filtration with hollow fiber membrane geometry to make process scale up quick and simple. The MiniKros module consists of Spectrum high quality hollow fibers potted in a symmetric housing with circulation inlet/outlet ports and two filtrate side ports. The hollow fiber membrane geometry and flow dynamics provide consistent filtration performance, direct scalability for production and high product recovery essential for pharmaceutical and diagnostic process development. All modules are autoclavable or are available irradiated (irr).

Dimensions:

Dimensions:

SA (cm2)Scale LengthID (mm)TL (cm)L (cm)EL (cm)
250-10501xFL18.827.622.320.8
1500-31001xFL31.227.622.320.8
3200-66002xFL31.251.046.044.1

Specifications:

Housing:Clear and pigmented Polysulfone
Connections:1/2 inch hose barb inlet/outlet ports
Female Luer Lok filtrate (FLL)
Potting:Polyurethane
Process Volume:300 mL to 100 Liters
Surface Area:5 to 6,600 cm2
MembraneFiber IDMWCO
Mixed Cellulose Ester (ME)0.6 mm0.2 µm, 0.1 µm
Polyethersulfone (PES)0.5 mm0.5 µm, 0.2 µm
Polysulfone (PS)0.5 mm0.05 µm, 20 nm (500 kD), 100 kD, 50 kD, 10 kD

Advantages of Disposability

  • Easier FDA Validation
  • Saves Money & Time
  • No Cross-Contamination
  • Less Down-Time
  • Low Shear
  • Directly Scalable for Production
  • Easy Retrofit for other HF Modules


Process Development Applications:

  • Diafiltration of Diagnostic Particles
  • Cell Washing and/or Harvesting
  • Clarification of Cellular Debris for Protein or Virus
  • Protein Purification and Concentration
  • Monoclonal Antibody Production
  • Purification and Concentration of Virus
  • NanoParticle Diafiltration

Filtration Resources:

Product Literature
Fundamentals of Filtration
Spectrum's Competitive Edge
Our HF Membranes vs. Others
Scalability of Process Modules
Application Guide
Chemical Compatibility Chart
Pore Size Chart

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RELATED PRODUCTS:

MiniKros Plus System
for volumes from 300 ml to 100 liters
Learn More >

MiniKros Pilot System
for volumes 10 to 1000 liters
Learn More >

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