Module Scalability

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Guide to Process Scalability for Spectrum Hollow Fiber Modules

Due to the consistent flow dynamics between hollow fiber membranes, Spectrum filters lend themselves to direct volume and surface area scalability by increasing the number of fibers while maintaining the same fiber flow path length. This allows you to easily transition from R & D (MicroKros®, MidiKros®, MiniKros® Sampler) to Process Development (MiniKros, CellFlo®) and on to Production (KrosFlo®, CellFlo). Module Inner Diameter (ID), module total length (TL), fiber length (L) and fiber effective length (EL) are shown below.

MicroKros Modules

for process volumes from 2 ml to 50 ml

Surface Area (cm²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
5 - 8	1/3xFL	3.5	10.2	10.2	8.0
8 - 11	2/3xFL	3.5	14.2	14.2	12.2
13 - 20	1xFL	3.5	23.2	23.2	21.2

MidiKros Modules

for process volumes from 20 ml to 200 ml

Surface Area (cm²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
20 - 55	1/3xFL	7.8	13.2	9.8	8.0
40 - 85	2/3xFL	7.8	17.3	13.7	11.8
60 - 145	1xFL	7.8	25.8	22.2	20.3

MiniKros Sampler Modules

for process volumes from 50 ml to 3 liters

Surface Area (cm²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
120 - 615	2/3xFL	18.8	18.5	13.9	12.2
165 - 1050	1xFL	18.8	27.6	22.3	20.8

MiniKros Sampler Plus Modules

for process volumes from 50 ml to 3 liters

Surface Area (cm²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
120 - 615	2/3xFL	18.8	18.5	13.9	12.2

MiniKros Modules

for process volumes from 300 ml to 100 liters

Surface Area (cm²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
200 - 1050	1xFL	18.8	27.6	22.3	20.8
1500 - 3100	1xFL	31.2	27.6	22.3	20.8
3200 - 6600	2xFL	31.2	51.0	46.0	44.1

MiniKros Plus Modules

for process volumes from 300 ml to 100 liters

Surface Area (cm²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
600 - 1050	1xFL	18.8	28.6	23.5	20.6
1800 - 3800	1xFL	31.2	28.6	23.5	20.6
3800 - 6600	2xFL	31.2	48.1	47.2	44.0
5700 - 9900	3xFL	31.2	73.8	69.0	65.8

KrosFlo Modules

for process volumes from 3 liters to 1,000 liters

Surface Area (m²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
0.32 - 1.6	1xFL	70.0	22.9	22.9	20.0
1.8 - 3.3	2xFL	70.0	46.7	46.0	41.5
2.8 - 5.1	3xFL	70.0	69.1	69.1	65.0

KrosFlo Plus Modules

for process volumes from 3 liters to 1,000 liters

Surface Area (m²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
0.32 - 1.6	1xFL	70.0	29.8	22.9	20.0
1.8 - 3.3	2xFL	70.0	53.0	46.0	41.5
2.8 - 5.1	3xFL	70.0	76.0	69.1	65.0

KrosFlo Max Modules

for process volumes from 50 liters to 5,000 liters

Surface Area (m²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
6.3 - 10.2	R65	116	73.5	62.8	49.9
9.3 - 13.9	3xFL	116	91.5	81.2	67.9
13.5 - 22.0	R85	116	131.1	120.6	107.5

CellFlo Modules

for process volumes from 3 liters to 1,000 liters

Surface Area	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
500 - 620 cm²	1xFL	18.8	27.6	22.3	20.8
1500 - 2000 cm²	1xFL	31.2	27.6	22.3	20.8
3200 - 4200 cm²	2xFL	31.2	51.0	46.0	44.1
0.32 - 1.3 m²	1xFL	70.0	22.9	22.9	20.0
1.8 - 2.6 m²	2xFL	70.0	47.0	46.0	41.5
2.8 - 4.1 m²	3xFL	70.0	69.1	69.1	65.0

CellFlo Plus Modules

for process volumes from 500 ml to 1,000 liters

Lab Scale Dimensions

Surface Area (m²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
500 - 620	1xFL	18.8	28.6	23.5	20.6
1500 - 2000	1xFL	31.2	28.6	23.5	20.6
3200 - 4200	2xFL	31.2	48.1	47.2	44.0
4800 - 6200	3xFL	31.2	73.8	69.0	65.8

Pilot Scale Dimensions

Surface Area (m²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
0.31 - 1.3	1xFL	70.0	28.1	22.9	20.0
1.8 - 2.6	2xFL	70.0	51.3	46.0	41.5
2.8 - 4.1	3xFL	70.0	74.4	69.1	65.0

CellFlo Max Modules

for process volumes from 50 liters to 5,000 liters

Surface Area (m²)	Scale Length	ID (mm)	TL (cm)	L (cm)	EL (cm)
5.3	R65	116	73.5	62.8	49.9
7.2	3xFL	116	91.5	81.2	67.9
11.3	R85	116	131.1	120.6	107.5

KrosFlo SIP

for process volumes from 50 liters to 1,000 liters

Surface Area (m²)	Size	ID (mm)	TL (cm)	L (cm)	EL (cm)
4.4 - 6.0	C	10.8	62.2	62.2	53.3

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